Cyclo-sh-pentapeptide-46 SP (国妆原备字20260057)
Official China NMPA New Cosmetic Ingredient Filing Dossier: Filing No. 国妆原备字20260057 (环 sh-五肽-46 SP) · Filed by Zhejiang Paite Biotech Co., Ltd. on 3 Apr.
Cyclo-sh-pentapeptide-46 SP (Official Chinese Name: 环 sh-五肽-46 SP) was officially filed with China’s National Medical Products Administration (NMPA) on 2026/4/3 under filing number 国妆原备字20260057 by Zhejiang Paite Biotech Co., Ltd. (Domestic (China)). Under China’s CSAR regulatory framework, this ingredient is currently in its mandatory 3-year post-market safety monitoring window (projected IECIC catalog inclusion date: 2029/4/3).
| NMPA Dossier Field | Official Filing Data & Status | Sourcing & Formulation Implication |
|---|---|---|
| NMPA Filing Number | 国妆原备字20260057 | Active filing under China CSAR new ingredient registry |
| English / INCI Reference | Cyclo-sh-pentapeptide-46 SP | Standardized cross-border R&D and COA lookup name |
| Official Name in Chinese | 环 sh-五肽-46 SP | Mandatory Chinese label name for China market entry |
| Registered Filer Entity | Zhejiang Paite Biotech Co., Ltd. | Authorization required from filer during 3-year monitoring |
| Filing Date & 3-Yr Window | Filed: 2026/4/3 → IECIC Inclusion Target: 2029/4/3 | Transitions to open IECIC catalog after 3 years without safety alerts |
| Target Turnkey Formats | BFS Single-Dose Ampoules / Hydrogel Masks / Dissolving Microneedle Patches | Available for global export OEM formulation & compliant alternatives |
Official Chinese INCI Names (IECIC) & 2026 Supply Lead-Time Quick Reference
| INCI Name | Official Name in Chinese (NMPA IECIC) | 2026 Supply Disruption, Stockout & Lead-Time Status | US FDA / EU CosIng Limit & Turnkey OEM Formats |
|---|---|---|---|
| Bakuchiol | 补骨脂酚 (Bǔ Gǔ Zhī Fēn) | ⚠️ Botanical seed-extracted grade (≥99%): 4–6 wk lead time (seasonal crop price fluctuations). Bio-fermented grade: No stockout / 2-wk lead time. | Clean retinol alternative; no EU Annex III cap. Top formats: Unit-dose barrier serum pods & hydrogel eye masks. |
| Colloidal Oatmeal | 胶体燕麦 / 燕麦 (AVENA SATIVA) 仁粉 | ✅ Stable supply (2–3 wk lead time); zero force majeure alerts. Ultra-fine USP grade requires verified beta-glucan COA. | US FDA OTC Skin Protectant Monograph active. Top formats: Soothing hydrocolloid barrier patches & single-serve cream pods. |
| Alpha-Arbutin | α-熊果苷 (Alpha-Xióng Guǒ Gān) | ⚠️ High demand ahead of EU reformulation deadlines (3–4 wk lead time); requires Hydroquinone impurity < 10 ppm. | EU CosIng Annex III limit: ≤ 2.0% face cream, ≤ 0.5% body lotion. Top format: Light-shielded single-dose brightening ampoules. |
| Salicylic Acid | 水杨酸 (Shuǐ Yáng Suān) | ✅ Ample global capacity (2 wk lead time); encapsulated & micronized patch-grade demand up +65% YoY. | US FDA OTC Acne Monograph (0.5%–2.0%); EU Annex III ≤ 2.0%. Top format: OTC hydrocolloid & microneedle acne patches. |
| Sodium DNA (PDRN) | DNA 钠 (DNA Nà) | 🔥 Tight lead time on pharmaceutical salmon-trout grade (5–7 wks); vegan ginseng/microalgae PDRN scaling rapidly. | K-Beauty Olive Young #1 surge ingredient. Top format: Dissolving microneedle patches & sterile BFS unit-dose vials. |
Pick your category — get recalls & regulation alerts weekly
Leave your email and the category you make: each week we tell you what was recalled or noticed in the EU and US, which deadlines are close, and who just raised money. Or use RSS. Free; unsubscribe anytime.
- EU recalls and US Prop 65 notices in your category
- Upcoming regulatory deadlines
- Opportunities filtered for your role